L 10.0.1.2/32 is directly connected, GigabitEthernet0/0 + - replicated route, % - next hop overrideġ0.0.0.0/8 is variably subnetted, 6 subnets, 2 masksĬ 10.0.0.2/32 is directly connected, Loopback0Ĭ 10.0.1.0/30 is directly connected, GigabitEthernet0/0 O - ODR, P - periodic downloaded static route, H - NHRP, l - LISP Ia - IS-IS inter area, * - candidate default, U - per-user static route I - IS-IS, su - IS-IS summary, L1 - IS-IS level-1, L2 - IS-IS level-2 N1 - OSPF NSSA external type 1, N2 - OSPF NSSA external type 2Į1 - OSPF external type 1, E2 - OSPF external type 2 P2P Links Between RoutersĪssign IP addresses on the network 10.0.0.0/30 to R1 and R2.Ĭodes: L - local, C - connected, S - static, R - RIP, M - mobile, B - BGPĭ - EIGRP, EX - EIGRP external, O - OSPF, IA - OSPF inter area Then start all nodes and open consoles on VPCS nodes and Cisco 7200 routers. Put two VPCS nodes (PC-1, PC-2) and two Cisco 7200 routers (R1, R2).Ĭonnect them as shown in the figure above. In this step, we make reachable between PC-1 and PC-2 via R1 and R2 with static routing. Build a Network with Static Routing Physical Layer You are now ready to create your own network. Give your new project a Name and click OK: The Preferences window displays showing the settings you have configured through the setup wizard. If a green idle-PC value is NOT shown then click the Idle-PC finder button to find an idle-PC value. It is important for optimum GNS3 performance that an idle-PC value be selected. Make sure that the Default RAM is 512 MiB. The directory where the decompressed image is stored will be displayed.Ĭonfirm the Platform selection, and configure the router Name. This is recommended for a better user experience. GNS3 can decompress IOS images to allow for quicker booting of routers in your GNS3 topologies. You will need to provide your own images to use them with GNS3. The Cisco IOS image we assume in this session is. The New IOS router template window displays.Ĭlick Browse, select the Cisco IOS image, and click Open. On this next screen, select Add an IOS router using a real IOS image (supported by Dynamips), and click OK. Once the connection to the local server has been validated, you will see a brief summary. This is required to allow GNS3 to control your network.Īfter clicking Next, you should get a validation screen. You will be prompted to allow root uBridge. Select Run only legacy IOS on my computer, check Don’t show this again in the wizard, and click Next. The Setup Wizard is displayed when GNS3 starts up for the first time. #GNS3 IDLE TIMER INSTALL#If you are using Homebrew, you can easily install them with: The GNS3 official installation guides can be found on. We highly recommend using macOS and this guide assumes that you are on macOS. In this session, you do not need VirtualBox. #GNS3 IDLE TIMER SOFTWARE#In this session, we will build some IP networks using a network software emulator GNS3 that supports Cisco routers.
0 Comments
#DOES ZINIO PRO REPLACE ZINIO READER PORTABLE#If not for the magazines, this is a great gift for all you bookworms out there looking to get their dose of boredom literature on the go using their portable computer. I downloaded it at work computer and brought it home to use on Powerbook, which is where I created Zinio account and. Other great apps like Zinio are Kobo, Freebook Sifter, Icecream Ebook Reader and. The best alternative is Calibre Web, which is both free and Open Source. I am a subscriber of PC Magazine and its as close as it can get to having a physical copy of it in my hands. Hi Guys, I subscribed to Macworld with Zinio. There are more than 25 alternatives to Zinio for a variety of platforms, including Online / Web-based, Android, Windows, iPhone and iPad. It also provides a huge collection of magazines available for subscriptions which can be automatically downloaded to the reader. It has offices in San Francisco and New York with several franchisees worldwide. Using the offline reader, you can make notes and annotations on the go, which it keeps with your user id on zinio. Founded in 2001, Zinio offers the sale and distribution of printed material in digital format. Zinio provides a reading experience which is very close to the real deal through a flash player and through its Zinio Reader for offline reading. And best of all, they are available to read both online and offline! From the press release: Quote: Zinio, the global leader in digital publishing technology and services, today announced the launch of Zinio Reader 4, built using Adobe AIR. Zinio has provided over 100 all time classics Pride and Prejudice, Sense and Sensibility, Beowulf and the likes. They just announced a new version of their PC app, and it’s based on Adobe Air. While I’m not really a fan of reading novels or books, I must say reading them on my notebook has given me second thoughts about it ( although it still can never persuade me to read Harry Potter! ). Now you can free download this screencast software and take the following simple guide to capture screencasts on your computer. Moreover, it carries additional functions that allow you to edit, transcribe, and export the screencasts with high quality. This recommended screencasting software can help you record whatever video and audio playing throughmonitor’s screen and speaker with exactly the original image/sound quality. #FREE SCREENCAST SOFTWARE HOW TO#Powerful editing features and save screencasts in any popular video/audio/image format.įree Download for macOS How to record screen and create screencasts.Make screencasts with full screen or customized area and real-time drawing.Record online videos, 2D/3D gameplay, webcam, video/audio chats, music and more.Capture computer screen/webcam, record audio and take screenshots.Easily create screencasts on Mac/Windows PC with high quality.Best Screencast Software - Screen Recorder What’s more, it carries many other useful functions to ensure you output a file you really like. At the first part, we like to show you the best screencasting software, Screen Recorder to capture screen and audio on both Windows 10/8/7/XP/Vista PC and Mac with high quality. When we talk about what the best screencast software is, besides the screen capturing, we also want more features like editing. NO.1 Best Screencast Software (Windows/Mac)- Screen Recorder You can get some basic features of each screencasting software and then pick your preferred one to create screencasts with ease. #FREE SCREENCAST SOFTWARE FOR MAC#Here in this post, we make a list of 5 best screencast software for Mac and Windows PC. If you want to make compelling and high-quality screencasts, you are at the right place. Here comes the question, what is the best screencast software? So it’s quite easy to take screencasts as long as you get one good screencast software. Good thing is, there is an entire range of screencasting software shared on the internet. When it comes to creating screencasts on your Windows or Mac computer, screencast software plays an important role. For instance, you may want to make a how-to video guide for eLearning, video game, for answering customers’queries, and for marketing purpose. Capturing and sending screencasts can be a quick and effective way to share information or knowledge in many different situations. LONG, A.: “Parmenides on Thinking Being” in J. and SCHOFIELD, M.: The Presocratic Philosophers, Cambridge, Cambridge University Press, 1986. and RAVEN, J.E.: The Presocratic Philosophers, Cambridge, Cambridge University Press, 1957. HÜLSZ PICCONE, E.: Lógos, Heráclito y los orígenes de la filosofía, México, UNAM, 2011= KAHN, C.H.: The Art and Thought of Heraclitus, Cambridge, Cambridge University Press, 1979. Hülsz (ed.) Nuevos Ensayos sobre Heráclito, México, U.N.A.M., 2009, pp. HERMANN, A.: “Parmenides versus Heraclitus?” in E. Graham (eds.) Presocratic Philosophy, Essays in honour of Alexander Mourelatos, Aldershot, Ashgate, 2002, pp. GRAHAM, D.: “Heraclitus and Parmenides” in V. GALLOP, D.: Parmenides of Elea, Fragments, A Texts and Translation with an Introduction, Toronto, University of Toronto Press, 1984=1991=2000. Aubenque (ed.) Études sur Parménide, Tome II, Paris, Vrin, 1987, pp. 277-293.ĬOXON, A.H.: The Fragments of Parmenides, Assen/Maastricht, Van Gorcum, 1986.įRÈRE, J.: “Parménide et l’ordre du monde”, in P. Aubenque (ed.) Études sur Parménide, Tome II, Paris, Vrin, 1987,pp. M.: “Parménide Sophiste, la citation aristotélicienne du fr. Aubenque (éd.) Études sur Parménide, Tome II, Paris, Vrin, 1987,pp. 45-62.īRAGUE, R.: “La vraisemblance du faux: Parm. Studi di filosofia antica, Perugia, Aquaplano,2010,pp. En este artículo intento defender la tesis de que ambos pensadores no sólo comparten visiones epistemológicas, sino también una cierta descripción ontológica que se podría sintetizar diciendo que ambos afirman que el lógos común (para decirlo con Heráclito) o el intelecto estable (para decirlo con Parménides) captan y afirman la unidad de lo que es real.īOSSI, B.:“Parménides, DK 28 B 16: ¿el eslabón perdido?”, in S. Análogamente, cuando es captado por el noûs errante, vagabundo o débil, no se comprende la unidad básica de lo real (Parménides). Por otra parte, el ámbito de la multiplicidad vista y oída por los sentidos, cuando es interpretado por ‘almas bárbaras’, no es comprendido en lo común y uno (Heráclito). Ambos filósofos distinguen dos ámbitos: por una parte, el ámbito único, común, idéntico para todos, que puede ser captado por el lógos común o el noûs estable, que sigue un método correcto de interpretación de lo real. Sin embargo, hay en ellos una significativa comprensión común de las cosas (aunque en diferentes contextos), y no solamente una analogía accidental de comprensión. Different pharmacological agents have been tested, but the use of iso-osmolar or hypo-osmolar contrast agents along with continuous hydration before, during, and after the intervention are the only methods that have currently achieved adequate nephroprotection.Suele pensarse que Heráclito es exclusivamente el filósofo del fluir, de la diversidad y de la oposición mientras que Parménides defiende la unidad inmóvil. As there is no specific treatment available for this condition, emphasis should be placed on prevention. It is the third leading cause of in-hospital acute kidney injuries, and it leads to an increase in morbidity and mortality of the population. Contrast-induced nephropathy is defined as an absolute (≥ 0.5 mg/dL) or relative increase (≥ 25%) of the serum creatinine within 24-72 hours post-exposure to the contrast media. It is estimated that the incidence is about 0-5% among the population with normal renal function however it can reach 12-27% among people with altered baseline renal function. The use of contrast media in the diagnostic and therapeutic medical arsenal can cause adverse effects, such as renal toxicity and acute kidney injury, known as contrast-induced nephropathy. Se han probado distintos agentes farmacológicos, sin embargo, hoy en día los únicos métodos que han logrado asegurar adecuada nefroprotección son el uso de agentes de contraste isoosmolares o de baja osmolaridad junto con hidratación continua del paciente antes, durante y después de la intervención. Por tanto, el énfasis se realiza en la prevención. No se dispone de un tratamiento específico para esta entidad. Es la tercera causa de injuria renal aguda intrahospitalaria y conlleva un aumento en la morbimortalidad de la población. La nefropatía inducida por contraste se define como un aumento absoluto (≥ 0,5 mg/dl) o relativo (≥ 25%) de la creatinina sérica en 24-72 h postexposición al medio de contraste. Se estima que en la población con función renal normal la incidencia es del 0-5% sin embargo, en personas con alteración de la función renal basal puede llegar a un 12-27%. El uso de medios de contraste dentro del arsenal diagnóstico y terapéutico médico puede ocasionar efectos adversos como toxicidad renal e injuria renal aguda, conocida como nefropatía inducida por contraste. Kinetic comparisons of a panel of increasingly decorated structural analogues imply that the binding is specific, and the small molecule core provides a privileged scaffold for further pharmaceutical development of a novel, allosteric drug. Furthermore, Michaelis–Menten kinetics and fluorescence data both suggest the simple, acetaminophen derivatives are non-competitive in binding to the enzyme. These analogues display encouraging in vitro inhibition of porcine heart LDH, including micromolar K i values and a maximum inhibition of up to 50% in the steady state. The present study examined structural analogues of this proposed inhibitor to gauge its potency and attempt to elucidate the molecular mechanism of action. The possibility of allosteric inhibition of LDH was postulated on the basis of theoretical docking studies of a small molecule inhibitor to LDH. Current inhibition strategies, employing substrate or cofactor analogues, are insufficiently specific for use as pharmaceutical agents. Lactate dehydrogenase (LDH) has recently garnered attention as an attractive target for cancer therapies, owing to the enzyme's critical role in cellular metabolism. |
Details
AuthorWrite something about yourself. No need to be fancy, just an overview. ArchivesCategories |